Clinical studies show Nattokinase supports cardiovascular health.

NutraMedix Nattokinase NSK-SD40® is extracted from natto, a food that the Japanese have consumed for centuries.  Natto is made from boiled soybeans fermented with Bacillus Subtills var.m natto, and nattokinase is a product of the fermentation process.

In contrast to its name, nattokinase is unrelated to the known kinases and is instead a serine protease.  It has been used to support heart health in traditional Japanese health practices for centuries.

NutraMedix Nattokinase NSK-SD40®, utilizes a pure, non-GMO, nonirradiated, vitamin K2-free nattokinase from Japan Bio Science Laboratory.  According to JBSL, it was the first to isolate and market nattokinase, has patented the process to remove vitamin K2 from nattokinase for optimal cardiovascular support; and has a large body of research behing the product, generating two new clinical studies per year.

NutraMedix Nattokinase NSK-SD40® is recognized by the Japan Health and Nutrition Food Authorization and the Japan Nattokinase Association, and has been recognized as a novel food in the European Union.  To be approved by the JNKA, a nattokinase product must be produced by fermentation with Bacillus Subtilis var. natto, the dose must contain more than 2,000 FU per dose, must meet safety measures and the product ingredients must have been confirmed by JNKA’s certified labs.

NutraMedix Nattokinase NSK-SD40® is free of dairy and gluten. NutraMedix rigorously follows current good manufacturing practices, as do their suppliers, including stringent ID testing, microbial testing, and healvy-metal testing on both raw materials and after encapsulation

Cardiovascular Support

Nattokinase may help with cardiovascular support through several methods: healthy fibrinolytic activity support, healthy blood-pressure support, and healthy circulation support.

Fibrinolytic Support

Nattokinase helps support healthy fibrinolytic activity via several mechanisms. Nattokinase can hydrolyze both fibrin and plasmin, supports the conversion of endogenous pro-urokinase to urokinase, and helps maintain PAI-1 and t-PA already within normal range, all of which are foundational for healthy fibrinolytic activity.  Nattokinase may also help maintain D-dimer, fibrin, factor VII and VIII, and partial thromboplastin time already within the normal range.  Notably, nattokinase does not inhibit the formation of fibrin from fibrinogen, and therefore, does not affect the healing response.

Blood Pressure Support

Nattokinase may help with healthy blood-pressure support.  In a systematic review and meta-analysis of six randomized, controlled trials with a total of 546 participants, the researchers concluded that nattokinase showed significant support for both systolic blood pressure and diastolic blood pressure already within the normal range.

In a randomized, controlled trial, 73 participants age 20-80 were given nattokinase (2000FU/capsule) or a placebo daily for 8 week.  Compared to the pacebo group, the nattokinase group received significant support for both systolic and diastolic blood pressure already within the normal range.

In a placebo-controlled, multicenter trial, 79 North American participants were randomly assigned to 100mg NutraMedix Nattokinase NSK-SD40®  per day or a placebo, daily for 8 weeks.  Compared to the placebo group, the treatment group experienced significant support for maintaining both  systolic and diastolic blood pressure already within the normal range, through the was more pronounced in men.

Circulation Support

Nattokinase may help support and maintain healthy circulation. In a double blind, placebo-controlled crossover study, male participants were randomly assigned to a single dose of 2,000 FU of nattokinase or a placebo.  Two hours later, the participants immersed their hands for 1 minute in cold water (10 degrees C).  Compared to the placebo group, the nattokinase group experienced significant support for normalization of skin temperature and blood flow without changes in cardiac output or heart rate.

Healthy Inflammatory-Response Support

Nattokinase may help with healthy inflammatory-response support. In a study examining the effect of nattokinase on high-sensitivity C-reactive protein,, participants were given a single 2,000 FU capsule of NSK_SD nattokinase.  Measurements were taken at baseline and again at 2, 4, 8, and 24 hours.  During the study, nattokinase helped maintain hsCRP already within the normal range, with greater support for levels in the higher range of normal.

Safety and Cautions

This product contains soybeans. Nattokinase is generally well tolerated and has been used safely in amount up to 2,000 FU daily for up to 3 years.

When taken with anticoagulant or antiplatelet drugs, nattokinase may increase the risk of bleeding. Rarely, nattokinase has been associated with hemorrhage. Theoretically, nattokinase may have additive effects when taken with hypotensive drugs.

Safety is not documented in breastfeeding or pregnant women or children under age 3, due to insufficient safety research.

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